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Postdoctoral Positions at the University of Michigan Medical School

Joshi Alumkal Lab

The Joshi Alumkal Lab at the University of Michigan is recruiting a post-doc focused on transcriptional regulation and lineage plasticity/drug resistance in prostate cancer. The position is intended for a highly-motivated individual with an MD and/or PhD with expertise in cell and molecular biology, biochemistry, or epigenetics. Experience with cancer research is preferred.

The Alumkal Laboratory’s main emphasis is to understand how genomic and epigenomic changes contribute to lethal prostate cancer progression. We use biochemical, genomic, and epigenomic approaches in cellular models to clarify mechanisms by which key transcriptional regulators function. The most important goals of our studies are to identify therapies that effectively target and interdict lethal prostate cancer progression and to conduct innovative clinical trials designed to validate the molecular and clinical effectiveness of novel therapeutic agents. 

Good oral and written communication skills and willingness to work in a team environment are essential. Salary is commensurate with experience. Our goal is that trainees and staff develop both critical, independent thinking skills and proficiency with a variety of state of the art techniques to solve pressing human health problems. We strongly believe in equality of opportunity and a respectful workplace. Please apply through the U-M hiring portal here (post-doc).  For questions, please contact the Alumkal Lab at alumkalinfo@umich.edu.

Fort Lab at the Kellogg Eye Center

The Fort Lab at the Kellogg Eye Center has two main projects, both centered around neurodegeneration. The first project is focusing on understanding the function and regulation of intrinsic protective mechanisms taking place in the retina in response to various cellular stress and diseases. They are currently studying the role and regulation of the small heat shock protein called alphaA-crystallin in the retina in the context of diabetes and other retinal neurodegenerative diseases in models ranging from cell and rodent models to non-human primates and post-mortem human tissues. The ultimate goal is through this understanding to develop new tools and potential therapies for neurodegenerative diseases.

The second main project of the laboratory is using our unique bank of human samples to get a better understanding of the diabetic retinopathy pathophysiology using a non-targeted multi-omics approach. While animal model studies have yielded a tremendous amount of information, the field has been struggling to translate those findings because of the lack of understanding of the human pathology, a gap that this project is working on filling.

The main focus of the posted position is to characterize the impact of the specific posttranslational modification on the chaperone function of alphaA-crystallin in retinal neurons and glia, its impact on neurodegeneration and neuroinflammation, and to assist in characterizing the multi-omics signature of human diabetic retinopathy.

Responsibilities

As a postdoctoral trainee in the Fort Lab, the candidate will primarily focus on the characterization and understanding of the chaperone activity of alphaA-crystallin in neuronal and glial cells, and its regulation by post-translational modifications including specific phosphorylation. As a second project, the postdoctoral trainee will assist in the management of the multi-omics analysis of human tissues from diabetic donors. Working with the biostatistician, the fellow will help with the pathway analysis and validation of the analysis with orthogonal methods in order to define the disease signature and its progression. In addition the candidate will be participating in the management of aspects of the laboratory “life” as well as staff and student members of the group. This includes but is not limited to day to day management and training of junior lab members and participation in management and preparation of general and specific resources for the whole group.

Required Qualifications

The Fort Lab is seeking a highly-motivated individual with a PhD. in cell biology, physiology, and/or neuroscience. Significant experience in cell culture (primary and/or cell lines), and/or in omics analysis is preferred. The successful candidate must be very organized, meticulous, self-motivated, and capable of working in a group/collaborative setting. The applicant needs to be comfortable with teaching in the context of the laboratory settings and eager to interact with the rest of the group.

Interested applicants should email Patrice E. Fort, PhD for additional information. 

Categories: Fellowships