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MSCI 301 Topics in Molecular Medicine (1): Topics related to the molecular pathogenesis, diagnosis and treatment of disease.
MSCI 302 Clinical Measurement (1): This course is a mix of basic and social sciences and is designed to train students for a better understanding of physiological and psychological measurement within the medical research.
MSCI 303 Drug Development Process (1): Introduces the rationale for, practical aspects of, and new issues in drug and device development policies and regulations.
MSCI 304 Medical Informatics (0.5): This course is an overview of medical informatics topics that affect the clinical researcher.
MSCI 305 Bioinformatics (0.5): Introduction to computational concepts and issues relevant to genomic, microarray and proteomics data analysis, especially in the context of clinical and cancer research.
MSCI 490 Independent Study (1-3) : Permission of instructor and department required.
MSCI 499 Research Project (2) : Development and presentation of a research project while participating in the program. Students present a seminar on the project, prepare a grant application, and submit a manuscript for publication
Related Courses
IGP 401 Biochemistry I (1): Structures and properties of proteins, nucleic acids, and polymers, complex and simple carbohydrates, and lipids; thermodynamic principles applied to biologic systems; molecules; structural correlates and functional expressions.
IGP 405 Cell Biology (1): Structure and function of cells and their organelles. Morphological, molecular, and physiological approaches to solving cell-biological problems.
IGP 407 Human and Primate Gross Anatomy (2) : Gross anatomy and embryology. Lecture, dissection, and demonstration. Permission of instructor required.
IGP 410 Molecular Biology (1): Topics in molecular biology and the mechanisms of gene and cellular regulation. Prerequisites: Past or simultaneous enrollment in IGP 401 or equivalent.
IGP 415 Biological Imaging: Principles and Applications (1): Introduction to modern techniques of image processing.
IGP 420 Molecular Basis of Drug Addiction (1): General principles of drug action at the molecular level. Topics: receptor theory, drug metabolism, pharmacokinetics, drug discovery, pharmacology of various important classes of therapeutic agents.
IGP 425 Advanced Topics in Drug Discovery (1): Key precedents and contemporary topics in drug discovery research in academia and industry. Principles of drug design and action, pharmacogenetics, macromolecular target identification and characterization, bioassays and animal models of disease, study design and information management.
IGP 430 Genetics (1): Genetics of prokaryotic and eukaryotic organisms; gene regulation and variation; chromosome structure and behavior; linkage and recombination; quantitative and population genetics; biochemical and developmental genetics; and manipulation of genes in organisms, including humans.
IGP 431 Advanced Topics in Mammalian Genetics (1): Eukaryotic genetics with particular reference to mammalian systems. Topics include chromosome behavior and disorders, somatic and germline genetics, gene mapping, developmental and biochemical genetics, quantitative and population genetics, pedigree analysis, and human genetics.
IGP 433 Advanced Microbial Pathogenesis (1): Properties of microorganisms important in the pathogenesis genesis of infectious diseases. Emphasis on molecular aspects of virulence as they relate to host-parasite interactions.
IGP 435 Receptors and Effectors (1): Integrated discussion of different superfamilies of signaling receptors and their effectors. Pathways discussed include G-protein linked, growth factors and cytokines, nuclear receptors and transcription factors.
IGP 436 Evolutionary Morphology (1): Readings on evolutionary morphology. Lecture and discussion.
IGP 440 Immunology (1): An integrated view of contemporary immunology: antigens, antibodies, humoral and cell-mediated immune responses, cellular interactions, and regulation of immune responses.
IGP 442 Microbiology (1): Structure and function, taxonomy and replication of infectious agents. Host-parasite interactions and microbial diseases. Prerequisites: IGP 405, IGP 410, and IGP 401 or equivalent.
IGP 447 Vascular Biology (1): Introduction to current topics in vascular biology: leukocyte-endothelial recognition; inflammation; hemostasis and thrombosis; angiogenesis in development and cancer; cellular and molecular basis of atherosclerosis. Prerequisites: IGP 401, IGP 405, IGP 410.
IGP 450 Tumor Cell Biology (1): Basic aspects of the neoplastic phenotype, including morphologic, biochemical, genetic, cytogenetic, and other features; regulation of cell proliferation and differentiation; basic concepts in molecular mechanisms of chemical, viral, and radiation carcinogenesis; solid tumor growth, progression, and metastasis; tumor immunology.
IGP 455 Developmental Biology (1): Survey of current models in mammalian and nonmammalian development. Discussion of experimental papers.
IGP 456 Topics in Developmental biology: Signaling molecules and birth Defects (1): This class examines, through short lectures but primarily paper discussions, the different ways in which disrupted developmental signaling leads to birth defects. We will examine the normal and abnormal developments of multiple tissue.
IGP 460 Cellular and Molecular Aspects of the Cytoskeleton (1): Structure, function, and biochemistry of major elements of the cytoskeleton; microtubules, intermediate filaments, and microfilaments. Topics include associated proteins, junctions, and cell movement.
IGP 462 Eukaryotic Molecular Biology and Genetics (1): Structure and expression of genetic information in eukaryotic organisms, emphasizing chromosome structure and replication, genomic organization, nuclear events involved in RNA synthesis, and transcriptional and translational control mechanisms. Prerequisites: IGP 410 or equivalent.
IGP 465 Macromolecular Structure and Function (1): Selected topics in the structure and function of proteins and nucleic acids; conformational studies of GTP binding proteins and kinases, enzyme mechanisms and active site ligands, structural basis of protein DNA interaction, catalytic RNA.
IGP 466 Structural Basis for Signal Transduction (1): The structural and thermodynamic basis by which protein- protein or protein-nucleic acid interactions mediate signal transduction. Signaling pathways used to explore how the structural biological mechanisms underlying these pathways can be experimentally determined and understood.
IGP 470 Advanced Virology (1): Molecular biology of representative animal viruses. Patterns of viral transcription, gene-protein relationships, and leukemogenesis and tumorigenesis.
IGP 472 Advanced Immunology I (1): Contemporary topics in immunology. Topics include cellular and humoral regulatory processes, expression and regulation of molecules and genes involved in lymphatic antigen receptors, and the structure and function of the major histocompatibility complex and other alloantigen systems.
IGP 475 Virology (1): Mechanisms of genome replication, control of gene expression, and protein functions are analyzed in RNA and DNA viruses.
IGP 477 Primate Evolutionary Morphology (1): Factual and theoretical background in key issues of primate evolution and morphology.
IGP 478 Biostatistics for the Life Sciences (1): Probability, descriptive statistics, sampling distributions, statistical inference, and confidence intervals as applied to the basic and life sciences. Methods include two sample t-tests and chi square tests, analysis of variance, regression and correlation, and nonparametric methods. Statistical packages are used for applications.
IGP 480 Molecular Mechanisms of Carcinogenesis (1): Current literature relating experimental approaches and recent discoveries in the fields of cell biology, virology, and molecular genetics to mechanisms of carcinogenesis. Advanced level.
IGP 494 Colloquium on Integrity in Biomedical Research (0): Required by National Institutes of Health (NIH) but does not count as one of the required IGP courses.
IGP 495 Science and Society (1): Exploration of the foundations of modern science and discussion of how these ideas impact social issues in the biomedical sciences (creationism, abortion, euthanasia, eugenics, cryogenics, replacement therapies, animal rights).
IGP 496-1,2,3 Introduction to Life Science Research (0)(0)(1): Provides first-year IGP students with tools to develop the knowledge base and skill set necessary for competent research.
IGP 590 Research (1-3) : Independent investigation of selected problems pertaining to thesis or dissertation.
PUB_HLTH 301 Behavior, Society, and Health (1): The interplay of social structure, technology, culture, and demography on patterns of health, illness, and health behavior. Application of theories of behavioral change for solving public health problems, including stages of change, relapse prevention, social advertising, and social marketing methods for use in primary care and community settings.
PUB_HLTH 302 Introduction to Biostatistics (1): Descriptive and inferential statistical methods: statistical graphics, exploratory data analysis, classical measures of central tendency and variability, relative standing, hypothesis testing, analysis of variance, bivariate linear correlation and regression, chi-square, and sample size estimation.
PUB_HLTH 303 Environmental Health Sciences (1): Broad introduction to analysis of the health consequences of exposure to air, weather, food, the workplace, and other special environments contaminated by biological, chemical, and physical agents. Designed for the environmental nonspecialist.
PUB_HLTH 304 Introduction to Epidemiology (1): Introduction to epidemiology and its uses. Measures of disease occurrence, common sources and types of data, important study designs, and sources of error in epidemiologic studies and epidemiologic methods. (The Feinberg School of Medicine course MDM-2 may be substituted for this course.)
PUB_HLTH 310 Topics in Public Health I (0): Exploration of topics in public health, focusing on the health of the population of Chicago.
PUB_HLTH 311 Topics in Public Health II (0): An exploration of topics in the history of public health. Prerequisites: PUB_HLTH 310 or permission of program director.
PUB_HLTH 312 Topics in Public Health III (1): An exploration of the structure and content of advocacy initiatives aimed at improving public health. Prerequisites: PUB_HLTH 310, PUB_HLTH 311, or permission of program director.
PUB_HLTH 313 Topics in Public Health IV (0): A further exploration of public health issues affecting the people of Chicago.
PUB_HLTH 314 Topics in Public Health V (0): An introduction to the public health infrastructure. Prerequisites: PUB_HLTH 313 or permission of program director.
PUB_HLTH 315 Topics in Public Health VI (1): History of medicine and public health education and practice in the United States; potential synergies of medicine and public health practice. Prerequisites: PUB_HLTH 313, PUB_HLTH 314, or permission of program director.
PUB_HLTH 390 International Public Health I (1): Introduction to major health problems in the developing world and approaches to their solution. Students will learn about research and intervention strategies, donor policies,and major players in international health.
PUB_HLTH 392 International Perspectives on Violence: Public Health and Law (1): Covers national and international aspects of violence: epidemiology, causes/risk factors, and interventions. Topics are gun violence; child abuse; domestic violence; and armed conflict/terrorism.
PUB_HLTH 393 Introduction to Health and Human Rights (1): Focuses on the relationship between health and human rights. Examines the origins of health and human rights concerns and defines the ethical obligations of health professionals in the face of human rights violations. Provides an overview of human rights violations in the world and an analysis of the physical and psychological consequences of human rights abuses.
PUB_HLTH 410 Field Experience in Public Health (1): An approved field placement in a public health setting. Prerequisites: Prerequisite:permission of instructor.
PUB_HLTH 412 Control and Prevention of Infectious Disease in Public Health (1): Infectious disease from the perspective of the community health practitioner. Introduction to infectious disease epidemiology, with a focus on modes of transmission, vulnerable hosts, primary prevention of infection, and public health initiatives to control and prevent infectious outbreaks.
PUB_HLTH 413 Public Health Nutrition (1): Introduction to nutrition from the perspective of the community rather than the individual. Includes the scientific basis for nutritional requirements and recommendations, nutrition through the life span, and the role of nutrition in health promotion and disease prevention.
PUB_HLTH 414 Violence as a Public Health Problem (1): Theories of violence and conceptual models. Specific violence syndromes (gangs, child abuse, etc.). Examination and evaluation of a violence prevention/intervention program, using the analysis framework established in class. Prerequisites: Prerequisite:PUB_HLTH 304.
PUB_HLTH 415 Health Promotion (1): Professional preparation for work in disease prevention and health promotion (DP/HP): factors influencing personal health decisions; causes and solutions of racial/ethnic disparities; integration of DP/HP into medical and public health practice; federal data sets and role of federal agencies.
PUB_HLTH 421 Intermediate Biostatistics (1): This course is designed to familiarize students further with epidemiologic and statistical techniques applied to cross-sectional and case-control studies. Prerequisites: Permission of instructor, OR PUB_HLTH 304, PUB_HLTH 302, and PUB_HLTH 422 or concurrent registration in PUB_HLTH 422.
PUB_HLTH 422 Intermediate Epidemiology (1): Build upon material learned in PUB_HLTH 304 Intro to Epidemiology. Focus on design, conduct, interpretation of observational studies in human populations: ecologic and migrant, cas-contrl, and cohort. Prerequisites: PUB_HLTH 302 Intro to Biostatistics and PUB_HLTH 304 Intro to Epidemiology (or Medical Decision Making II).
PUB_HLTH 431 Decision Analysis and Models of Medical Decision Making (1): Quantitative techniques intended to inform decision makers at the bedside as well as at the policy-making level. Topics include probability, Bayes’ theorem, sensitivity and specificity of diagnostic tests, Bayesian decision analysis, utility assessment, cost-effectiveness analysis, and expert systems.
PUB_HLTH 432 Technology Assessment in Health Care (1): Underlying theoretical paradigms in technology assessment, medical effectiveness, and health policy. Methodolgical knowledge for critically evaluating, performing, and presenting systematic evidence-based reviews of medical effectiveness. Students critique, evaluate, and interpret literature evidence on medical effectiveness. Prerequisites: PUB_HLTH 302 and PUB_HLTH 304.
PUB_HLTH 433 Health Economics: Principles and Applications for Public Health (1): Overview of key economic theories and principles relevant to the health sector, including consumer demand, provider behavior and supply of services, the role of information and intermediaries, public regulation, and the production of public health care. Evolution in health delivery and financing will also be explored in relation to the changing economic environment. The course will emphasize the application of these principles and theories to public health by examining implications for medical effectiveness and outcomes research.
PUB_HLTH 434 Data Analysis Techniques for Health Services Research (1): Data analysis techniques used by medical researchers for retrospective studies. Students will critically assess and estimate modes commonly found in publications like The Journal of the American Medical Association and Health Services Research Journal.
PUB_HLTH 435 Design and Analysis Strategies in Health Services Research (1): Methodological and study design knowledge for critically evaluating, performing, and presenting health services research. Focus on real-world research proficiency and the theories underlying health services research.
PUB_HLTH 436 Public Health Law (1): Overview of law and legal system, terminology in legal writing, state and federal court systems. Learn basic legal scholarship to help in researching public health issues in judicial and legislative source materials. Prerequisites: PH 304 Intro to Epidemiology (or Medical Decision Making II) or permission of instructor.
PUB_HLTH 437 Applied Epidemiologic Data Analysis (1): Design and analysis of epidemiologic studies, emphasis on applying methodology learned in Intermediate Biostatistics/Epidemiology or equivalent coursework. Practical aspects of conducting research from defining statistically testable hypothesis to building database and generating results.
PUB_HLTH 438 Survey Design and Methodology (1): Methodological issues and hands-on experience in the design, implementation, analysis, and interpretation of surveys and questionnaires in public health research.
PUB_HLTH 439 Qualitative Research Methods (1): Focus on qualitative research methods including investigation of research design, sampling, data management, analysis, report writing. Address reliability, validity, ethical issues; relationship between qualitative and quantitative research. Students are encouraged to bring a data set.
PUB_HLTH 441 Ethical Issues in Clinical Research (0.5) : Debate and discussion of ethical issues surrounding clinical research studies, including merits of research proposals, both historical and contemporary, from the perspective of an institutional review board (IRB) charged with the protection of research subjects. Issues considered include research studies involving prospective cohorts, studies of vulnerable populations, clinical trials,and use of genetic data in epidemiologic research studies.
PUB_HLTH 442 Artificial Epidemics and Changes in Human Culture (1): Twentieth-century epidemics that developed as a result of changes in human culture, with a focus on outbreaks of noninfectious disorders, including pellagra, lung cancer, and occupational lead poisoning. Epidemics are explored, with an emphasis on cultural changes leading to the outbreak, the epidemiologic methods used to investigate it, and efforts aimed at prevention. Readings include classic research papers from public health literature, speeches, editorials, biographical material, excerpts from fiction, and articles from the popular press.
PUB_HLTH 444 Advanced Decision Analysis (1): Advanced decision-analytic methods useful in medical decision modeling. Includes probabilistic theory of hazard rates and modeling of age-dependent mortality; Markov and stochastic tree modeling; techniques for multiway sensitivity analysis, such as probabilistic sensitivity analysis and information-value analysis; use of spreadsheets for Markov models; and software for stochastic tree modeling. Review medical decision-analytic literature and explore theoretical underpinnings of models. A project using decision analysis software is required.
PUB_HLTH 445 Writing and Peer Reviewing for Publication (0.5) : Hands-on, advanced course in writing for publication in the medical science journals; how to be a successful peer reviewer; not a course in basic writing. The student will be expected to prepare an article through two peer review cycles to be ready to submit to a journal. Uses real-world practices.
PUB_HLTH 446 The Design, Conduct, and Analysis of Clinical Trials (1): Fundamentals of clincial trials, including design, conduct, and analysis and interpretation of trial results. Topics include commonly used designs, methods for randomization, blinding and sample size determinations, choice of controls, collaborative/multicenter trial requirements and operational issues, data management and data quality issues, interim analysis methods, critical review of clincial trial results, and statistical techniques for analyzing data. Prerequisites: PUB_HLTH 421 and PUB_HLTH 302 (or CLIN_PSY 426) and PUB_HLTH 304.
PUB_HLTH 499 Independent Study (1-3) : N/A
PUB_HLTH 523 Chronic Disease Epidemiology (1): Current issues in chronic disease epidemiology, with an emphasis on cardiovascular disease and cancer. Study design and analysis, measurement issues, and special concerns of multisite studies are examined.
PUB_HLTH 524 Cardiovascular Disease Epidemiology (1): Cardiovascular disease with critical analysis of current epidemiologic literature; study methodological issues, contemporary findings, and recommendations for future research.
PUB_HLTH 525 Molecular Epidemiology (1): Major theoretical concepts and practical issues involved in conducting research in molecular biomarkers in human populations.
PUB_HLTH 526 Cancer Epidemiology (1): Basic concepts and issues in cancer epidemiology; statistics; etiology and risk factors for major cancer sites; research design and interpretation in context of cancer epidemiology; molecular and cellular basis of carcinogenesis pertaining to cancer occurrence in populations.
PUB_HLTH 527 Cancer Screening: Principles and Practice (0.5) : Overview of key theoretical principles and pragmatic issues faced in conducting research in cancer screening. Emphasis on research concepts; not a survey of current knowledge on cancer screening. Discussion of specific examples from medical literature.
PUB_HLTH 528 Behavioral Science in Cancer Prevention and Control (0.5) : Basic concepts and issues of behavioral science in cancer prevention and control. Major theoretical models in behavioral science, behavioral risk factors for cancer, behavioral clinical trials in cancer prevention and control, measurement issues in behavioral studies. Prerequisites: PH 302 Intro to Biostats, PH 304 Intro to Epi (MDM II), and/or Permission of Instructor.
PUB_HLTH 529 Cancer Chemoprevention (0.5) : Concepts and issues relevant to cancer chemoprevention: molecular pharmacology of therapeutic intervention targeted to early stages of carcinogenesis for major cancer sites; function of specific target, characteristics of a drug; choice and characteristics of an endpoint biomarker; and research design and interpretation related to molecular and cellular carcinogenesis. Students should have prior understanding of cancer biology. Prerequisites: PH 302 Intro to Biostats, PH 304 Intro to Epi (MDM II), and/or Permission of Instructor.
PUB_HLTH 560 Culminating Experience in Public Health (0-2) : Development and presentation of a culminating research or service project in consultation with an adviser or advisory committee. Student presents a seminar and submits a paper on the project.
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