IGP 401 Biochemistry I (1) Structures and properties of proteins, nucleic acids, and polymers, complex and simple carbohydrates, and lipids; thermodynamic principles applied to biologic systems; molecules; structural correlates and functional expressions.
IGP 405 Cell Biology (1) Structure and function of cells and their organelles. Morphological, molecular, and physiological approaches to solving cell-biological problems.
IGP 407 Human and Primate Gross Anatomy (2) Gross anatomy and embryology. Lecture, dissection, and demonstration. Permission of instructor required.
IGP 410 Molecular Biology (1) Topics in molecular biology and the mechanisms of gene and cellular regulation. Prerequisite: Past or simultaneous enrollment in IGP 401 or equivalent.
IGP 415 Biological Imaging: Principles and Applications (1) Introduction to modern techniques of image processing.
IGP 420 Molecular Basis of Drug Addiction (1) General principles of drug action at the molecular level. Topics: receptor theory, drug metabolism, pharmacokinetics, drug discovery, pharmacology of various important classes of therapeutic agents.
IGP 425 Advanced Topics in Drug Discovery (1) Key precedents and contemporary topics in drug discovery research in academia and industry. Principles of drug design and action, pharmacogenetics, macromolecular target identification and characterization, bioassays and animal models of disease, study design and information management.
IGP 430 Genetics (1) Genetics of prokaryotic and eukaryotic organisms; gene regulation and variation; chromosome structure and behavior; linkage and recombination; quantitative and population genetics; biochemical and developmental genetics; and manipulation of genes in organisms, including humans.
IGP 431 Advanced Topics in Mammalian Genetics (1) Eukaryotic genetics with particular reference to mammalian systems. Topics include chromosome behavior and disorders, somatic and germline genetics, gene mapping, developmental and biochemical genetics, quantitative and population genetics, pedigree analysis, and human genetics.
IGP 433 Advanced Microbial Pathogenesis (1) Properties of microorganisms important in the pathogenesis genesis of infectious diseases. Emphasis on molecular aspects of virulence as they relate to host-parasite interactions.
IGP 435 Receptors and Effectors (1) Integrated discussion of different superfamilies of signaling receptors and their effectors. Pathways discussed include G-protein linked, growth factors and cytokines, nuclear receptors and transcription factors.
IGP 436 Evolutionary Morphology (1) Readings on evolutionary morphology. Lecture and discussion.
IGP 440 Immunology (1) An integrated view of contemporary immunology: antigens, antibodies, humoral and cell-mediated immune responses, cellular interactions, and regulation of immune responses.
IGP 442 Microbiology (1) Structure and function, taxonomy and replication of infectious agents. Host-parasite interactions and microbial diseases. Prerequisites: IGP 405, IGP 410, and IGP 401 or equivalent.
IGP 447 Vascular Biology (1) Introduction to current topics in vascular biology: leukocyte-endothelial recognition; inflammation; hemostasis and thrombosis; angiogenesis in development and cancer; cellular and molecular basis of atherosclerosis. Prerequisites: IGP 401, IGP 405, IGP 410.
IGP 450 Tumor Cell Biology (1) Basic aspects of the neoplastic phenotype, including morphologic, biochemical, genetic, cytogenetic, and other features; regulation of cell proliferation and differentiation; basic concepts in molecular mechanisms of chemical, viral, and radiation carcinogenesis; solid tumor growth, progression, and metastasis; tumor immunology.
IGP 455 Developmental Biology (1) Survey of current models in mammalian and nonmammalian development. Discussion of experimental papers.
IGP 460 Cellular and Molecular Aspects of the Cytoskeleton (1) Structure, function, and biochemistry of major elements of the cytoskeleton; microtubules, intermediate filaments, and microfilaments. Topics include associated proteins, junctions, and cell movement.
IGP 462 Eukaryotic Molecular Biology and Genetics (1) Structure and expression of genetic information in eukaryotic organisms, emphasizing chromosome structure and replication, genomic organization, nuclear events involved in RNA synthesis, and transcriptional and translational control mechanisms. Prerequisite: IGP 410 or equivalent.
IGP 465 Macromolecular Structure and Function (1) Selected topics in the structure and function of proteins and nucleic acids; conformational studies of GTP binding proteins and kinases, enzyme mechanisms and active site ligands, structural basis of protein DNA interaction, catalytic RNA.
IGP 466 Structural Basis for Signal Transduction (1) The structural and thermodynamic basis by which protein- protein or protein-nucleic acid interactions mediate signal transduction. Signaling pathways used to explore how the structural biological mechanisms underlying these pathways can be experimentally determined and understood.
IGP 470 Advanced Virology (1) Molecular biology of representative animal viruses. Patterns of viral transcription, gene-protein relationships, and leukemogenesis and tumorigenesis.
IGP 472 Advanced Immunology I (1) Contemporary topics in immunology. Topics include cellular and humoral regulatory processes, expression and regulation of molecules and genes involved in lymphatic antigen receptors, and the structure and function of the major histocompatibility complex and other alloantigen systems.
IGP 475 Virology (1) Mechanisms of genome replication, control of gene expression, and protein functions are analyzed in RNA and DNA viruses.
IGP 477 Primate Evolutionary Morphology (1) Factual and theoretical background in key issues of primate evolution and morphology.
IGP 478 Biostatistics for the Life Sciences (1) Probability, descriptive statistics, sampling distributions, statistical inference, and confidence intervals as applied to the basic and life sciences. Methods include two sample t-tests and chi square tests, analysis of variance, regression and correlation, and nonparametric methods. Statistical packages are used for applications.
IGP 480 Molecular Mechanisms of Carcinogenesis (1) Current literature relating experimental approaches and recent discoveries in the fields of cell biology, virology, and molecular genetics to mechanisms of carcinogenesis. Advanced level.
IGP 494 Colloquium on Integrity in Biomedical Research (0) Required by National Institutes of Health (NIH) but does not count as one of the required IGP courses.
IGP 495 Science and Society (1) Exploration of the foundations of modern science and discussion of how these ideas impact social issues in the biomedical sciences (creationism, abortion, euthanasia, eugenics, cryogenics, replacement therapies, animal rights).
IGP 496-1, 2, 3 Introduction to Life Science Research (0) (0) (1) Provides first-year IGP students with tools to develop the knowledge base and skill set necessary for competent research.
IGP 590 Research (1, 2, or 3) Independent investigation of selected problems pertaining to thesis or dissertation.
